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Antibody-mediated depletion of both CD4+ or CD8+ T cells diminished the anti-tumour consequences of SHP099, suggesting a vital role for T cell responses inside the protective results of PTPN11 inhibition. Of Observe, the growth of B16-F10 melanomas was suppressed in mice with certain deletion of Ptpn11 in myeloid lineages when compared to Handle st

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